CSNK2A1 Gene Summary [Human]
Casein kinase II is a serine/threonine protein kinase that phosphorylates acidic proteins such as casein. It is involved in various cellular processes, including cell cycle control, apoptosis, and circadian rhythm. The kinase exists as a tetramer and is composed of an alpha, an alpha-prime, and two beta subunits. The alpha subunits contain the catalytic activity while the beta subunits undergo autophosphorylation. The protein encoded by this gene represents the alpha subunit. Multiple transcript variants encoding different protein isoforms have been found for this gene. [provided by RefSeq, Apr 2018]
Details
| Type | Protein Coding |
| Official Symbol | CSNK2A1 |
| Official Name | casein kinase 2 alpha 1 [Source:HGNC Symbol;Acc:HGNC:2457] |
| Ensembl ID | ENSG00000101266 |
| Bio databases IDs | |
| Aliases | casein kinase 2 alpha 1, Casein kinase II subunit alpha |
| Synonyms | casein kinase 2 alpha 1, casein kinase 2, alpha 1 polypeptide, casein kinase 2 α 1, casein kinase 2, α 1 polypeptide, Casein kinase II alpha 1 polypeptide, Casein kinase II α 1 polypeptide, CK1 alpha2, CK2, CK2A1, CK2 alpha, CK2 α, Cka1, Cka2, CKII, CK II alpha, Ck II Alpha Subunit, CK II α, Ck II α Subunit, Csnk2a1-rs4, OCNDS |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CSNK2A1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein serine/threonine kinase
- protein kinase
- beta-catenin binding
- heat shock protein binding
- protein phosphatase regulator
- protein binding
- Protein kinase domain
- identical protein binding
- kinase
- Serine/Threonine protein kinases, catalytic domain
- kinase domain
- Protein Kinases, catalytic domain
- ribonucleoprotein binding
Pathways
Biological processes and signaling networks where the CSNK2A1 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- schizophrenia
- neoplasia
- edema
- breast cancer
- squamous cell lung cancer
- lung squamous cell carcinoma
- breast carcinoma
- epithelial cancer
- cholangiocarcinoma
- cholangiocarcinoma cancer
role in cell
- proliferation
- apoptosis
- binding in
- cell death
- survival
- binding
- number
- migration
- phosphorylation in
- formation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- cell cortex
- Plasma Membrane
- cytosol
- chromosome
- nucleoplasm
- PML nuclear bodies
- chromatin
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human CSNK2A1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- signal transduction
- negative regulation of double-strand break repair via homologous recombination
- positive regulation of cell proliferation
- chaperone-mediated protein folding
- positive regulation of protein catabolic process
- response to DNA damage stimulus
- protein phosphorylation
- double-strand break repair
- positive regulation of cell growth
- rhythmic process
- disassembly by symbiont of host cell PML body
- negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
- apoptotic process
- Wnt receptor signaling pathway
- positive regulation of Wnt receptor signaling pathway
- regulation of cell cycle
- protein stabilization
- peptidyl-serine phosphorylation
- negative regulation of translation
- negative regulation of apoptotic signaling pathway
- peptidyl-threonine phosphorylation
- negative regulation of proteasomal ubiquitin-dependent protein catabolic process
Cellular Component
Where in the cell the gene product is active
- nucleus
- protein kinase CK2 complex
- PML body
- PcG protein complex
- cytosol
- plasma membrane
- Sin3-type complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ATP binding
- identical protein binding
- protein binding
- Hsp90 protein binding
- protein serine/threonine kinase activity
- kinase activity