Serpinb8 Gene Summary [Rat]
Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to be involved in epithelial cell-cell adhesion and negative regulation of endopeptidase activity. Predicted to be located in cytosol. Predicted to be active in cytoplasm and extracellular space. Human ortholog(s) of this gene implicated in peeling skin syndrome 5. Orthologous to human SERPINB8 (serpin family B member 8). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Serpinb8 |
| Official Name | serpin family B member 8 [Source:RGD Symbol;Acc:1309833] |
| Ensembl ID | ENSRNOG00000002396 |
| Bio databases IDs | |
| Aliases | serpin family B member 8 |
| Synonyms | C18orf53, CAP-2, PI-8, PROTEINASE INHIBITOR 8, PSS5, serpin family B member 8 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Serpinb8 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SERine Proteinase INhibitors (serpin) family
- serine protease inhibitor activity
- protein binding
- Serpin (serine protease inhibitor)
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- peeling skin syndrome 5
- uterine serous papillary cancer
- psoriasis
- vertigo
role in cell
- expression in
- proliferation
- invasion by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Serpinb8 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- epithelial cell-cell adhesion
- negative regulation of endopeptidase activity
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular vesicular exosome
- cytoplasm
- cytosol
Molecular Function
What the gene product does at the molecular level
- serine-type endopeptidase inhibitor activity
- protein binding