GALR1 Gene Summary [Human]
The neuropeptide galanin elicits a range of biological effects by interaction with specific G-protein-coupled receptors. Galanin receptors are seven-transmembrane proteins shown to activate a variety of intracellular second-messenger pathways. GALR1 inhibits adenylyl cyclase via a G protein of the Gi/Go family. GALR1 is widely expressed in the brain and spinal cord, as well as in peripheral sites such as the small intestine and heart. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | GALR1 |
| Official Name | galanin receptor 1 [Source:HGNC Symbol;Acc:HGNC:4132] |
| Ensembl ID | ENSG00000166573 |
| Bio databases IDs | |
| Aliases | galanin receptor 1 |
| Synonyms | galanin receptor 1, GALNR, GALNR1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human GALR1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- neuropeptide binding
- Cholecystokinin A receptor, N-terminal
- galanin receptor
- 7 transmembrane receptor (rhodopsin family)
- protein binding
- seven-transmembrane G protein-coupled receptor superfamily
- polypeptide hormone binding
Pathways
Biological processes and signaling networks where the GALR1 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- pheochromocytoma formation
- pheochromocytoma
- neoplasia
- IgA nephropathy
- thoracic aortic aneurysms and dissections
- depressive disorder
- seizures
- global developmental delay with intellectual disability
role in cell
- expression in
- activation in
- proliferation
- growth
- colony formation by
- excitatory postsynaptic potential
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- membrane fraction
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human GALR1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of adenylate cyclase activity
- positive regulation of cortisol secretion
- neuropeptide signaling pathway
- adenylate cyclase-activating G-protein coupled receptor signaling pathway
- positive regulation of transcription from RNA polymerase II promoter
- elevation of cytosolic calcium ion concentration
Cellular Component
Where in the cell the gene product is active
- membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- G-protein coupled peptide receptor activity
- neuropeptide binding
- galanin receptor activity
- protein binding
- peptide hormone binding