CENPV Gene Summary [Human]
Predicted to enable carbon-sulfur lyase activity and metal ion binding activity. Involved in pericentric heterochromatin assembly; positive regulation of cytokinesis; and regulation of chromosome organization. Acts upstream of or within ameboidal-type cell migration. Located in several cellular components, including midbody; nucleus; and spindle midzone. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Retained Intron |
| Official Symbol | CENPV |
| Official Name | centromere protein V [Source:HGNC Symbol;Acc:HGNC:29920] |
| Ensembl ID | ENSG00000166582 |
| Bio databases IDs | |
| Aliases | centromere protein V |
| Synonyms | 3110013H01Rik, centromere protein V, p30, PRR6, RGD1565681 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CENPV often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Glutathione-dependent formaldehyde-activating enzyme
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- microtubule cytoskeleton
- midbody
- microtubule organizing centers
- cytosol
- nuclear pores
- nucleoplasm
- spindle pole
- nuclear envelope
- central spindle
- meiotic spindles
- kinetochores
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human CENPV gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell division
- centromere complex assembly
- ameboidal cell migration
- regulation of chromosome organization
- centromeric heterochromatin assembly
- positive regulation of cytokinesis
Cellular Component
Where in the cell the gene product is active
- nucleus
- nuclear membrane
- microtubule cytoskeleton
- spindle midzone
- cytosol
- midbody
- kinetochore
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- carbon-sulfur lyase activity
- protein binding
- metal ion binding