FBXW7 Gene Summary [Human]
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene was previously referred to as FBX30, and belongs to the Fbws class; in addition to an F-box, this protein contains 7 tandem WD40 repeats. This protein binds directly to cyclin E and probably targets cyclin E for ubiquitin-mediated degradation. Mutations in this gene are detected in ovarian and breast cancer cell lines, implicating the gene's potential role in the pathogenesis of human cancers. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2012]
Details
| Type | Protein Coding |
| Official Symbol | FBXW7 |
| Official Name | F-box and WD repeat domain containing 7 [Source:HGNC Symbol;Acc:HGNC:16712] |
| Ensembl ID | ENSG00000109670 |
| Bio databases IDs | |
| Aliases | F-box and WD repeat domain containing 7, archipelago homolog (Drosophila) |
| Synonyms | 1110001A17Rik, AGO, CDC4, DEDHIL, F-box and WD-40 domain protein 7, F-box and WD repeat domain containing 7, FBW6, FBW7, Fbwd6, FBX30, FBXO30, FBXW6, hAgo, hCdc4, LOC102551266, SEL-10 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human FBXW7 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ubiquitin protein ligase binding
- F-box domain superfamily
- protein binding activity, bridging
- WD domain, G-beta repeat
- WD40
- enzyme
- enzyme regulator activity
- protein binding
- enzyme activator activity
- identical protein binding
- phosphoprotein amino acid binding
- cyclin binding
- F-box domain
- WD40 repeats
- F-box-like
- substrate binding domain
Pathways
Biological processes and signaling networks where the FBXW7 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- metastasis
- neoplasia
- renal cancer
- edema
- clear-cell ovarian carcinoma
- clear cell ovarian cancer
- colorectal cancer
- prostate cancer
- epithelial cancer
- uterine corpus endometrioid carcinoma
role in cell
- accumulation in
- differentiation
- survival
- production in
- cell death
- proliferation
- expression in
- phosphorylation in
- activation in
- signaling in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- mother centriole
- Cytoplasm
- perinuclear region
- Golgi Apparatus
- Endoplasmic Reticulum
- Mitochondria
- cytosol
- nucleoplasm
- nucleoli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human FBXW7 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- DNA repair
- positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
- positive regulation of epidermal growth factor-activated receptor activity
- vasculogenesis
- regulation of circadian rhythm
- negative regulation of Notch signaling pathway
- negative regulation of SREBP-mediated signaling pathway
- positive regulation of ubiquitin-protein ligase activity
- vasculature development
- positive regulation of protein ubiquitination
- negative regulation of osteoclast development
- ubiquitin homeostasis
- lung development
- sister chromatid cohesion
- regulation of cell migration involved in sprouting angiogenesis
- regulation of protein localization
- lipid homeostasis
- protein destabilization
- negative regulation of gene expression
- proteasomal ubiquitin-dependent protein catabolic process
- Notch signaling pathway
- negative regulation of triglyceride biosynthetic process
- rhythmic process
- positive regulation of ERK1 and ERK2 cascade
- SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
- protein stabilization
- negative regulation of hepatocyte proliferation
- protein ubiquitination
- regulation of lipid storage
Cellular Component
Where in the cell the gene product is active
- nucleus
- perinuclear region of cytoplasm
- cytoplasm
- mitochondrion
- cytosol
- endoplasmic reticulum
- Golgi apparatus
- SCF ubiquitin ligase complex
- chromosome
- nucleolus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- ubiquitin protein ligase binding
- ubiquitin-protein ligase activator activity
- ubiquitin binding
- phosphothreonine binding
- cyclin binding
- protein binding, bridging