SCG5 Gene Summary [Human]
This gene encodes a secreted chaperone protein that prevents the aggregation of other secreted proteins, including proteins that are associated with neurodegenerative and metabolic disease. The encoded protein may be best known for its role in the trafficking and activation of prohormone convertase PC2 (encoded by Gene ID: 5126). Phosphorylation of the encoded protein has been shown to have an inhibitory effect on its chaperone function. This gene also produces a ARHGAP11A-SCG5 readthrough transcript and ARHGAP11A-SCG5 protein. [provided by RefSeq, Feb 2019]
Details
| Type | Protein Coding |
| Official Symbol | SCG5 |
| Official Name | secretogranin V [Source:HGNC Symbol;Acc:HGNC:10816] |
| Ensembl ID | ENSG00000166922 |
| Bio databases IDs | |
| Aliases | secretogranin V, prohormone convertase chaperone |
| Synonyms | 7B2, P7B2, secretogranin V, SGNE1, SgV |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human SCG5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- GTP binding
- Neuroendocrine protein 7B2 precursor (Secretogranin V)
- enzyme inhibitor activity
- alpha helix
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- diabetic nephropathy
- colorectal cancer
- schizophrenia
- idiopathic pulmonary fibrosis
- bleeding
- Alzheimer disease
- alopecia
- seizures
- hyperplasia
- bruising
role in cell
- expression in
- cell viability
- production in
- quantity
- mass
- abnormal morphology
- fibrillogenesis
- processing in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Nucleus
- granules
- cytosol
- trans Golgi network
- smooth endoplasmatic reticulum
- rough endoplasmatic reticulum
- secretory granules
- premelanosomes
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human SCG5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- neuropeptide signaling pathway
- regulation of hormone secretion
- peptide hormone processing
- intracellular protein transport
Cellular Component
Where in the cell the gene product is active
- nucleus
- secretory granule
- extracellular region
Molecular Function
What the gene product does at the molecular level
- GTP binding
- protein binding
- enzyme inhibitor activity
- unfolded protein binding
- enzyme regulator activity