STAT4 Gene Summary [Human]
The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is essential for mediating responses to IL12 in lymphocytes, and regulating the differentiation of T helper cells. Mutations in this gene may be associated with systemic lupus erythematosus and rheumatoid arthritis. Alternate splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Aug 2011]
Details
| Type | Protein Coding |
| Official Symbol | STAT4 |
| Official Name | signal transducer and activator of transcription 4 [Source:HGNC Symbol;Acc:HGNC:11365] |
| Ensembl ID | ENSG00000138378 |
| Bio databases IDs | |
| Aliases | signal transducer and activator of transcription 4 |
| Synonyms | DPMC, signal transducer and activator of transcription 4, SLEB11, STAT4 alpha, STAT4 α |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human STAT4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- transcription regulator
- STAT protein, DNA binding domain
- nucleic acid binding
- protein binding
- sequence-specific DNA binding
- identical protein binding
- SPXX motif
- STAT protein, all-alpha domain
- DNA binding
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- double-stranded DNA binding
- STAT_CCD
- Src homology 2 (SH2) domain
- transcription factor activity
- DNA-binding domain of Signal Transducer and Activator of Transcription (STAT)
- STAT protein, protein interaction domain
Pathways
Biological processes and signaling networks where the STAT4 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- systemic sclerosis
- rheumatoid arthritis
- Alzheimer disease
- celiac disease
- thyroid disease
- systemic lupus erythematosus
- epithelial cancer
- insulin-dependent diabetes mellitus
- diabetes mellitus
- sporadic amyotrophic lateral sclerosis
role in cell
- production in
- cytotoxicity
- expression in
- apoptosis
- activation in
- proliferation
- survival
- growth
- killing
- replication in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- cytosol
- nucleoplasm
- nuclear bodies
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human STAT4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- T-helper 1 cell differentiation
- cytokine-mediated signaling pathway
- response to interleukin-6
- positive regulation of transcription from RNA polymerase II promoter
- defense response
- response to peptide hormone stimulus
- regulation of cell proliferation
- interleukin-12-mediated signaling pathway
- regulation of transcription from RNA polymerase II promoter
- JAK-STAT cascade
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- cytosol
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- sequence-specific DNA binding transcription factor activity
- protein binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity