MS4A7 Gene Summary [Human]

This gene encodes a member of the membrane-spanning 4A gene family, members of which are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns in hematopoietic cells and nonlymphoid tissues. This family member is associated with mature cellular function in the monocytic lineage, and it may be a component of a receptor complex involved in signal transduction. This gene is localized to 11q12, in a cluster of other family members. At least four alternatively spliced transcript variants encoding two distinct isoforms have been observed. [provided by RefSeq, Jul 2008]

Details

Type
Protein Coding
Official Symbol
MS4A7
Official Name
membrane spanning 4-domains A7 [Source:HGNC Symbol;Acc:HGNC:13378]
Ensembl ID
ENSG00000166927
Bio databases IDs NCBI: 58475 Ensembl: ENSG00000166927
Aliases membrane spanning 4-domains A7
Synonyms 4SPAN2, 9130422I10Rik, A430103C15RIK, CD20L4, CFFM4, CFFMA, membrane spanning 4-domains A7, membrane-spanning 4-domains, subfamily A, member 7, MS4A8
Species
Human, Homo sapiens
OrthologiesMouseRat

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human MS4A7 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • protein binding
  • CD20-like family

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
  • rheumatoid arthritis
  • renal clear cell adenocarcinoma
  • renal clear cell cancer
  • keloid
regulated by

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Cytoplasm
  • cellular membrane
  • trans Golgi network

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the human MS4A7 gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • cell surface receptor signaling pathway

Cellular Component

Where in the cell the gene product is active
  • trans-Golgi network
  • plasma membrane

Molecular Function

What the gene product does at the molecular level
  • protein binding

Gene-Specific Assays for Results You Can Trust

Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.