IGFBP5 Gene Summary [Human]
Enables insulin-like growth factor I binding activity. Involved in several processes, including cellular response to cAMP; regulation of smooth muscle cell migration; and regulation of smooth muscle cell proliferation. Part of insulin-like growth factor ternary complex. Biomarker of pulmonary fibrosis. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | IGFBP5 |
| Official Name | insulin like growth factor binding protein 5 [Source:HGNC Symbol;Acc:HGNC:5474] |
| Ensembl ID | ENSG00000115461 |
| Bio databases IDs | |
| Aliases | insulin like growth factor binding protein 5 |
| Synonyms | IBP5, IGFBP-5P, insulin-like growth factor binding protein 5 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human IGFBP5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- IGF-binding site
- TY
- nuclear localization sequence
- heparin binding domain
- insulin-like growth factor binding
- receptor agonist activity
- central domain
- protein binding
- Insulin-like growth factor binding protein
- basic domain
- fibronectin binding
Pathways
Biological processes and signaling networks where the IGFBP5 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- epithelial neoplasia
- epithelial cancer
- cancer
- obesity
- papillomatosis
- breast cancer
- urothelial bladder carcinoma
- transitional cell bladder cancer
- organismal death
role in cell
- apoptosis
- proliferation
- expression in
- differentiation
- binding
- survival
- growth
- quantity
- adhesion
- colony formation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- cell surface
- Nucleus
- endoplasmic reticulum lumen
- extracellular matrix
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human IGFBP5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of growth
- regulation of insulin-like growth factor receptor signaling pathway
- negative regulation of insulin-like growth factor receptor signaling pathway
- positive regulation of insulin-like growth factor receptor signaling pathway
- negative regulation of osteoblast differentiation
- lung alveolus development
- striated muscle cell differentiation
- type B pancreatic cell proliferation
- negative regulation of smooth muscle cell proliferation
- osteoblast differentiation
- negative regulation of smooth muscle cell migration
- negative regulation of translation
- intracellular signal transduction
- mammary gland involution
- signal transduction
- insulin-like growth factor receptor signaling pathway
- female pregnancy
- response to growth hormone stimulus
- regulation of cell growth
- glucose homeostasis
- cellular response to cAMP
- hair follicle morphogenesis
- cellular response to organic cyclic compound
- negative regulation of cell migration
- positive regulation of protein kinase B signaling cascade
Cellular Component
Where in the cell the gene product is active
- insulin-like growth factor binding protein complex
- endoplasmic reticulum lumen
- extracellular space
- extracellular region
- insulin-like growth factor ternary complex
Molecular Function
What the gene product does at the molecular level
- protein binding
- fibronectin binding
- insulin-like growth factor I binding
- insulin-like growth factor II binding