ATG7 Gene Summary [Human]
This gene encodes an E1-like activating enzyme that is essential for autophagy and cytoplasmic to vacuole transport. The encoded protein is also thought to modulate p53-dependent cell cycle pathways during prolonged metabolic stress. It has been associated with multiple functions, including axon membrane trafficking, axonal homeostasis, mitophagy, adipose differentiation, and hematopoietic stem cell maintenance. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]
Details
| Type | Protein Coding |
| Official Symbol | ATG7 |
| Official Name | autophagy related 7 [Source:HGNC Symbol;Acc:HGNC:16935] |
| Ensembl ID | ENSG00000197548 |
| Bio databases IDs | |
| Aliases | autophagy related 7, ubiquitin-activating enzyme E1-like protein |
| Synonyms | 1810013K23Rik, Agp7, Apg7, APG7L, APG7-LIKE, Atg7l, autophagy related 7, Gm21553, GSA7, LOC105376952, SCAR31 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ATG7 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- E1-like protein-activating enzyme Gsa7p/Apg7p
- ThiF family
- protein homodimerization
- enzyme
- protein binding
- APG12 activating enzyme
- Ubiquitin-like modifier-activating enzyme ATG7 N-terminus
- E1_enzyme_family
- APG8 activating enzyme
Pathways
Biological processes and signaling networks where the ATG7 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- rheumatoid arthritis
- cancer
- multiple sclerosis
- neoplasia
- non-melanoma skin cancer
- obesity
- epithelial cancer
- gastrointestinal neoplasia
- dextran sodium sulfate-induced colitis
- metastasis
role in cell
- expression in
- migration
- accumulation
- production in
- cell viability
- cell death
- activation
- growth
- phosphorylation in
- activation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- secretory granule lumen
- ficolin-1-rich granule lumen
- Extracellular Space
- perinuclear region
- axonemes
- cytosol
- synapse
- axons
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ATG7 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein transport
- protein lipidation
- positive regulation of protein catabolic process
- cellular response to starvation
- macromitophagy
- regulation of circadian rhythm
- C-terminal protein lipidation
- mitochondrion degradation
- cellular response to nitrogen starvation
- autophagic vacuole assembly
- piecemeal microautophagy of nucleus
- rhythmic process
- autophagy
- positive regulation of apoptotic process
- defense response to virus
- cellular response to hyperoxia
- macroautophagy
- protein modification by small protein conjugation
- positive regulation of protein modification process
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- pre-autophagosomal structure
- cytosol
- secretory granule lumen
- extracellular region
- axoneme
Molecular Function
What the gene product does at the molecular level
- protein binding
- protein homodimerization activity
- APG8 activating enzyme activity
- APG12 activating enzyme activity