DRAM1 Gene Summary [Human]
This gene is regulated as part of the p53 tumor suppressor pathway. The gene encodes a lysosomal membrane protein that is required for the induction of autophagy by the pathway. Decreased transcriptional expression of this gene is associated with various tumors. This gene has a pseudogene on chromosome 4. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | DRAM1 |
| Official Name | DNA damage regulated autophagy modulator 1 [Source:HGNC Symbol;Acc:HGNC:25645] |
| Ensembl ID | ENSG00000136048 |
| Bio databases IDs | |
| Aliases | DNA damage regulated autophagy modulator 1, damage-regulated autophagy modulator |
| Synonyms | 1200002N14Rik, DNA-damage regulated autophagy modulator 1, DRAM, FLJ11259 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human DRAM1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Frag1/DRAM/Sfk1 family
- protein binding
Pathways
Biological processes and signaling networks where the DRAM1 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- systemic lupus erythematosus
- cerebral aneurysm
- cleft palate
- cleft lip
- Marfan syndrome
- Shigella infection
- abnormal posturing
- idiopathic scoliosis
role in cell
- cell viability
- proliferation
- survival
- quantity
- motility
- apoptosis
- permeabilization
- tethering
- disruption
- cell death
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- lysosome
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human DRAM1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- autophagy
- regulation of autophagy
- apoptotic process
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- lysosomal membrane
- lysosome
Molecular Function
What the gene product does at the molecular level
- protein binding