SUN5 Gene Summary [Human]
The protein encoded by this gene appears to play a role in the meiotic stage of spermatogenesis. The encoded protein localizes to the junction between the sperm head and body and may be involved in nuclear envelope reconstitution and nuclear migration. Mutations in this gene have been implicated in acephalic spermatozoa syndrome. [provided by RefSeq, May 2017]
Details
| Type | Protein Coding |
| Official Symbol | SUN5 |
| Official Name | Sad1 and UNC84 domain containing 5 [Source:HGNC Symbol;Acc:HGNC:16252] |
| Ensembl ID | ENSG00000167098 |
| Bio databases IDs | |
| Aliases | Sad1 and UNC84 domain containing 5, testis and spermatogenesis related gene 4 |
| Synonyms | 1700021O15Rik, dJ726C3.1, Riken cDNA 1700021o15, Sad1 and UNC84 domain containing 5, SPAG4L, SPAG4L-2, SPGF16, SRG4, TSARG4 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human SUN5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Sad1 / UNC-like C-terminal
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- inner nuclear membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human SUN5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- spermatid development
- spermatogenesis
Cellular Component
Where in the cell the gene product is active
- nuclear envelope
- nuclear inner membrane
- Golgi apparatus
- SUN-KASH complex
Molecular Function
What the gene product does at the molecular level
- protein binding
- protein anchor