Sun5 Gene Summary [Rat]

Predicted to enable protein-membrane adaptor activity. Predicted to be involved in spermatid development. Predicted to act upstream of or within protein-containing complex assembly; regulation of protein localization; and spermatogenesis. Predicted to be located in nuclear inner membrane. Predicted to be part of meiotic nuclear membrane microtubule tethering complex. Predicted to be active in nuclear envelope and sperm head-tail coupling apparatus. Human ortholog(s) of this gene implicated in spermatogenic failure 16. Orthologous to human SUN5 (Sad1 and UNC84 domain containing 5). [provided by Alliance of Genome Resources, Apr 2025]

Details

Type
Protein Coding
Official Symbol
Sun5
Official Name
Sad1 and UNC84 domain containing 5 [Source:RGD Symbol;Acc:1306357]
Ensembl ID
ENSRNOG00000027221
Bio databases IDs NCBI: 296289 Ensembl: ENSRNOG00000027221
Aliases Sad1 and UNC84 domain containing 5
Synonyms 1700021O15Rik, dJ726C3.1, Riken cDNA 1700021o15, Sad1 and UNC84 domain containing 5, SPAG4L, SPAG4L-2, SPGF16, SRG4, TSARG4
Species
Rat, Rattus norvegicus
OrthologiesHumanMouse

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Sun5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • Sad1 / UNC-like C-terminal
  • protein binding

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
  • acute myeloid leukemia
  • spermatogenic failure 16
regulated by
regulates
  • protein-protein complex
role in cell
  • development

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Nucleus
  • inner nuclear membrane

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the rat Sun5 gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • spermatid development
  • spermatogenesis

Cellular Component

Where in the cell the gene product is active
  • nuclear envelope
  • nuclear inner membrane
  • Golgi apparatus
  • SUN-KASH complex

Molecular Function

What the gene product does at the molecular level
  • protein binding
  • protein anchor

Gene-Specific Assays for Results You Can Trust

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