Sun5 Gene Summary [Mouse]
Predicted to enable protein-membrane adaptor activity. Involved in spermatid development. Acts upstream of or within protein-containing complex assembly; regulation of protein localization; and spermatogenesis. Located in sperm head-tail coupling apparatus. Human ortholog(s) of this gene implicated in spermatogenic failure 16. Orthologous to human SUN5 (Sad1 and UNC84 domain containing 5). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Sun5 |
| Official Name | Sad1 and UNC84 domain containing 5 [Source:MGI Symbol;Acc:MGI:1923657] |
| Ensembl ID | ENSMUSG00000027480 |
| Bio databases IDs | |
| Aliases | Sad1 and UNC84 domain containing 5 |
| Synonyms | 1700021O15Rik, dJ726C3.1, Riken cDNA 1700021o15, Sad1 and UNC84 domain containing 5, SPAG4L, SPAG4L-2, SPGF16, SRG4, TSARG4 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Sun5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Sad1 / UNC-like C-terminal
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- inner nuclear membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Sun5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- spermatid development
- spermatogenesis
Cellular Component
Where in the cell the gene product is active
- nuclear envelope
- nuclear inner membrane
- Golgi apparatus
- SUN-KASH complex
Molecular Function
What the gene product does at the molecular level
- protein binding
- protein anchor