DPEP2
DPEP2 Gene Summary
DPEP2 belongs to the membrane-bound dipeptidase (EC 3.4.13.19) family. These enzymes hydrolyze a variety of dipeptides, including leukotriene D4, the beta-lactam ring of some antibiotics, and cystinyl-bis-glycine (cys-bis-gly) formed during glutathione degradation (Habib et al., 2003 [PubMed 12738806]).[supplied by OMIM, Mar 2008]
Details
| Type | Protein Coding |
| Official Symbol | DPEP2 |
| Official Name | dipeptidase 2 [Source:HGNC Symbol;Acc:HGNC:23028] |
| Ensembl ID | ENSG00000167261 |
| Bio databases IDs | |
| Aliases | dipeptidase 2 |
| Synonyms | dipeptidase 2,F630103D06Rik,MBD-2 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- dipeptidase
- peptidase
- membrane dipeptidase
- metallo-dependent_hydrolases
- exopeptidase
Pathways
Biological processes and signaling networks where the DPEP2 gene plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- PLTP
- ARSK
- LRFN3
- TAFAZZIN
- GFPT2
- CEMIP2
- ADPGK
- JUN
- DPEP3
- CHST12
disease
- diabetes mellitus
- COVID-19
- organismal death
- lung adenocarcinoma formation
- lung adenocarcinoma
regulated by
- TRPS1
- PCSK9
- laquinimod
- PBMCs
- peripheral blood neutrophils
regulates
- leukotriene D4
- leukotriene
role in cell
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the DPEP2 gene, providing context for its role in the cell.
BIOLOGICAL PROCESS
Functions and activities the gene product is involved in
- leukotriene metabolic process
- proteolysis
CELLULAR COMPONENT
Where in the cell the gene product is active
- membrane
MOLECULAR FUNCTION
What the gene product does at the molecular level
- metallodipeptidase activity
- metal ion binding
- dipeptidase activity