ADPGK Gene Summary [Human]
ADPGK (EC 2.7.1.147) catalyzes the ADP-dependent phosphorylation of glucose to glucose-6-phosphate and may play a role in glycolysis, possibly during ischemic conditions (Ronimus and Morgan, 2004 [PubMed 14975750]).[supplied by OMIM, Mar 2008]
Details
| Type | Protein Coding |
| Official Symbol | ADPGK |
| Official Name | ADP dependent glucokinase [Source:HGNC Symbol;Acc:HGNC:25250] |
| Ensembl ID | ENSG00000159322 |
| Bio databases IDs | |
| Aliases | ADP dependent glucokinase |
| Synonyms | 2610017G09Rik, ADP-dependent glucokinase, RGD1306103 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ADPGK often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- ribokinase_pfkB_like
- ADP-specific Phosphofructokinase/Glucokinase conserved region
- alcohol group acceptor phosphotransferase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- metastasis
- organismal death
- prostate cancer
- tinnitus
regulates
- adenosine triphosphate
- lactic acid
- 2,3-diphosphoglycerate
- D-glucose
- PRKAA
- glucose-6-phosphate
- phosphoenolpyruvate
- glyceraldehyde-3-phosphate
role in cell
- survival
- expression in
- colony formation by
- migration
- phosphorylation in
- production in
- proliferation
- oxygen consumption in
- glycolytic capacity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Endoplasmic Reticulum
- endoplasmic reticulum membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ADPGK gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- glucose metabolic process
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- membrane
- endoplasmic reticulum
- extracellular region
Molecular Function
What the gene product does at the molecular level
- metal ion binding
- ADP-specific glucokinase activity