CHST12 Gene Summary
The protein encoded by this gene belongs to the sulfotransferase 2 family. It is localized to the golgi membrane, and catalyzes the transfer of sulfate to position 4 of the N-acetylgalactosamine (GalNAc) residue of chondroitin and desulfated dermatan sulfate. Chondroitin sulfate constitutes the predominant proteoglycan present in cartilage, and is distributed on the surfaces of many cells and extracellular matrices. Alternatively spliced transcript variants differing only in their 5' UTRs have been found for this gene. [provided by RefSeq, Aug 2011]
Details
| Type | Protein Coding |
| Official Symbol | CHST12 |
| Official Name | carbohydrate sulfotransferase 12 [Source:HGNC Symbol;Acc:HGNC:17423] |
| Ensembl ID | ENSG00000136213 |
| Bio databases IDs | |
| Aliases | carbohydrate sulfotransferase 12, chondroitin 4-sulfotransferase 2 |
| Synonyms | C4S-2,C4ST-2,carbohydrate sulfotransferase 12,carbohydrate sulphotransferase 12,Chondroitin 4-o-sulfotransferase,Chondroitin 4-o-sulphotransferase,FLJ00049,LOC100288594,LOC100291271,LOC100293682,LOC101927181 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- enzyme
- chondroitin 4-sulfotransferase
- Sulfotransferase family
Pathways
Biological processes and signaling networks where the CHST12 gene plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Golgi membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the CHST12 gene, providing context for its role in the cell.
biological PROCESS
Functions and activities the gene product is involved in
- chondroitin sulfate biosynthetic process
- dermatan sulfate biosynthetic process
- carbohydrate biosynthetic process
- proteoglycan biosynthetic process
cellular COMPONENT
Where in the cell the gene product is active
- membrane
- Golgi membrane
molecular FUNCTION
What the gene product does at the molecular level
- chondroitin 4-sulfotransferase activity
- sulfotransferase activity
- 3'-phosphoadenosine 5'-phosphosulfate binding