HDGFL2 Gene Summary [Human]
This gene encodes a member of the hepatoma-derived growth factor (HDGF) family. The protein includes an N-terminal PWWP domain that binds to methyl-lysine-containing histones, with specific binding of this protein to tri-methylated lysines 36 and 79 of histone H3, and di- and tri-methylated lysine 20 of histone H4. The protein functions in LEDGF/p75-independent HIV-1 replication by determining HIV-1 integration site selection. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Apr 2014]
Details
| Type | Protein Coding |
| Official Symbol | HDGFL2 |
| Official Name | HDGF like 2 [Source:HGNC Symbol;Acc:HGNC:14680] |
| Ensembl ID | ENSG00000167674 |
| Bio databases IDs | |
| Aliases | HDGF like 2, hepatoma-derived growth factor related protein 2 |
| Synonyms | HDGF-2, HDGF like 2, HDGFRP2, HRP-2, MGC2641, Similar to hepatoma-derived growth factor-related protein 2 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human HDGFL2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- histone binding
- protein binding activity, bridging
- PWWP domain
- PWWP (Pro-Trp-Trp-Pro) domain
- protein binding
- Lens epithelium-derived growth factor (LEDGF)
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human HDGFL2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- muscle organ development
- DNA repair
- chromatin remodeling
- positive regulation of cell growth
- muscle cell differentiation
- DNA recombination
- skeletal muscle tissue regeneration
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- methylated histone residue binding