Hdgfl2 Gene Summary [Rat]
Predicted to enable histone H3K27me3 reader activity; histone H3K9me2/3 reader activity; and methylated histone binding activity. Predicted to be involved in several processes, including DNA repair-dependent chromatin remodeling; positive regulation of double-strand break repair via homologous recombination; and skeletal muscle tissue regeneration. Located in cytoplasm and nucleus. Orthologous to human HDGFL2 (HDGF like 2). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Hdgfl2 |
| Official Name | HDGF like 2 [Source:RGD Symbol;Acc:621013] |
| Ensembl ID | ENSRNOG00000049142 |
| Bio databases IDs | |
| Aliases | HDGF like 2 |
| Synonyms | HDGF-2, HDGF like 2, HDGFRP2, HRP-2, MGC2641, Similar to hepatoma-derived growth factor-related protein 2 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Hdgfl2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- histone binding
- protein binding activity, bridging
- PWWP domain
- PWWP (Pro-Trp-Trp-Pro) domain
- protein binding
- Lens epithelium-derived growth factor (LEDGF)
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Hdgfl2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- muscle organ development
- DNA repair
- chromatin remodeling
- positive regulation of cell growth
- muscle cell differentiation
- DNA recombination
- skeletal muscle tissue regeneration
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- methylated histone residue binding