GGT6 Gene Summary [Human]
GGT6 belongs to the gamma-glutamyltransferase (GGT; EC 2.3.2.2) gene family. GGT is a membrane-bound extracellular enzyme that cleaves gamma-glutamyl peptide bonds in glutathione and other peptides and transfers the gamma-glutamyl moiety to acceptors. GGT is also key to glutathione homeostasis because it provides substrates for glutathione synthesis (Heisterkamp et al., 2008 [PubMed 18357469]).[supplied by OMIM, Oct 2008]
Details
| Type | Protein Coding |
| Official Symbol | GGT6 |
| Official Name | gamma-glutamyltransferase 6 [Source:HGNC Symbol;Acc:HGNC:26891] |
| Ensembl ID | ENSG00000167741 |
| Bio databases IDs | |
| Aliases | gamma-glutamyltransferase 6 |
| Synonyms | 9030405D14Rik, gamma-glutamyl transferase 6, γ-glutamyl transferase 6 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human GGT6 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Gamma-glutamyltranspeptidase
- peptidase
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human GGT6 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- glutathione biosynthetic process
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- membrane
Molecular Function
What the gene product does at the molecular level
- protein binding