CUL4A Gene Summary [Human]
CUL4A is the ubiquitin ligase component of a multimeric complex involved in the degradation of DNA damage-response proteins (Liu et al., 2009 [PubMed 19481525]).[supplied by OMIM, Oct 2009]
Details
| Type | Protein Coding |
| Official Symbol | CUL4A |
| Official Name | cullin 4A [Source:HGNC Symbol;Acc:HGNC:2554] |
| Ensembl ID | ENSG00000139842 |
| Bio databases IDs | |
| Aliases | cullin 4A |
| Synonyms | 2810470J21Rik, CUL4, Cullin 4a, RGD1563853 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CUL4A often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ubiquitin protein ligase binding
- ubiquitin protein ligase activity
- Nedd8 binding domain
- alpha helix
- protein binding activity, bridging
- Cullin protein neddylation domain
- Cullin family
- enzyme
- protein binding
- Cullin
- DDB1-interaction domain
Pathways
Biological processes and signaling networks where the CUL4A gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- gastric cancer
- squamous cell lung cancer
- neoplasia
- metastasis
- azoospermia
- breast cancer
- colorectal cancer
- small cell lung cancer
- large cell lung carcinoma
- large cell lung cancer
role in cell
- phosphorylation in
- binding in
- expression in
- apoptosis
- degradation in
- proliferation
- quantity
- activation
- migration
- number
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human CUL4A gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell proliferation
- DNA repair
- positive regulation of G1/S transition of mitotic cell cycle
- spermatogenesis
- hemopoiesis
- positive regulation of cell proliferation
- T cell activation
- positive regulation of protein catabolic process
- ribosome biogenesis
- intrinsic apoptotic signaling pathway
- response to DNA damage stimulus
- regulation of nucleotide-excision repair
- proteasomal ubiquitin-dependent protein catabolic process
- rhythmic process
- in utero embryonic development
- G1/S transition of mitotic cell cycle
- somatic stem cell maintenance
- cellular response to UV
- regulation of DNA damage checkpoint
- negative regulation of granulocyte differentiation
- protein ubiquitination
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- Cul4A-RING ubiquitin ligase complex
- CUL4 RING ubiquitin ligase complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- ubiquitin protein ligase binding