FAIM2 Gene Summary [Human]
Involved in regulation of neuron apoptotic process. Acts upstream of or within negative regulation of extrinsic apoptotic signaling pathway via death domain receptors. Located in membrane raft. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | FAIM2 |
| Official Name | Fas apoptotic inhibitory molecule 2 [Source:HGNC Symbol;Acc:HGNC:17067] |
| Ensembl ID | ENSG00000135472 |
| Bio databases IDs | |
| Aliases | Fas apoptotic inhibitory molecule 2, transmembrane BAX inhibitor motif containing 2 |
| Synonyms | 2900002L20Rik, AI854036, Fas apoptotic inhibitory molecule 2, LFG, LFG2, LOC100909872, LOC102551901, NGP35, NMP25, NMP35, TMBIM2 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human FAIM2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Inhibitor of apoptosis-promoting Bax1
- BAX inhibitor (BI)-1/YccA-like protein family
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- overnutrition
- obesity
- diabetes mellitus
- metastasis
- diabetic nephropathy
- non-small cell lung cancer
- organismal death
- morbid obesity
- gout
role in cell
- cell viability
- expression in
- cell death
- differentiation
- survival
- proliferation
- invasion by
- apoptosis
- quantity
- density
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- membrane fraction
- Cytoplasm
- perinuclear region
- cellular membrane
- vesicles
- Golgi Apparatus
- Endoplasmic Reticulum
- postsynaptic membrane
- Golgi membrane
- membrane rafts
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human FAIM2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cerebellar Purkinje cell layer development
- cerebellar granular layer development
- response to ischemia
- cerebellar Purkinje cell differentiation
- cerebellum development
- negative regulation of apoptotic process
- apoptotic signaling pathway
- regulation of neuron apoptotic process
- neuron apoptotic process
- negative regulation of apoptotic signaling pathway
- negative regulation of neuron apoptotic process
Cellular Component
Where in the cell the gene product is active
- postsynaptic membrane
- membrane
- membrane raft
- Golgi apparatus
- endoplasmic reticulum
Molecular Function
What the gene product does at the molecular level
- protein binding