ENTPD3 Gene Summary [Human]
This gene encodes a plasma membrane-bound divalent cation-dependent E-type nucleotidase. The encoded protein is involved in the regulation of extracellular levels of ATP by hydrolysis of it and other nucleotides. Multiple transcript variants have been described. [provided by RefSeq, May 2014]
Details
| Type | Protein Coding |
| Official Symbol | ENTPD3 |
| Official Name | ectonucleoside triphosphate diphosphohydrolase 3 [Source:HGNC Symbol;Acc:HGNC:3365] |
| Ensembl ID | ENSG00000168032 |
| Bio databases IDs | |
| Aliases | ectonucleoside triphosphate diphosphohydrolase 3 |
| Synonyms | CD39 antigen-like 3, CD39L3, ectonucleoside triphosphate diphosphohydrolase 3, HB6, NTPDase-3 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ENTPD3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- nucleoside-triphosphatase
- nucleoside-diphosphatase
- enzyme
- protein binding
- ASKHA_ATPase-like
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- pruritus
- ulcerative colitis
- androgenic alopecia
- keratocystic odontogenic tumor
- keratocystic odontogenic tumors
regulates
- adenosine triphosphate
- nucleoside triphosphate
- proinsulin
- PGAM5
- nucleoside diphosphates
role in cell
- degradation in
- number
- hydrolysis in
- molecular cleavage in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
- apical cell surfaces
- basolateral cell surfaces
- axons
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ENTPD3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- nucleoside diphosphate catabolic process
- nucleoside triphosphate catabolic process
Cellular Component
Where in the cell the gene product is active
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein binding
- apyrase activity
- uridine-diphosphatase activity
- guanosine-diphosphatase activity
- nucleoside-diphosphatase activity
- nucleoside-triphosphatase activity