MRPL58 Gene Summary [Human]
The protein encoded by this gene is a peptidyl-tRNA hydrolase and a vital component of the large mitochondrial ribosome. The encoded protein serves as a ribosome release factor for this ribosome, which translates mitochondrial genes. This protein may be responsible for degrading prematurely-terminated polypeptides and for reusing stalled ribosomes. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2014]
Details
| Type | Protein Coding |
| Official Symbol | MRPL58 |
| Official Name | mitochondrial ribosomal protein L58 [Source:HGNC Symbol;Acc:HGNC:5359] |
| Ensembl ID | ENSG00000167862 |
| Bio databases IDs | |
| Aliases | mitochondrial ribosomal protein L58 |
| Synonyms | 1110001A02Rik, 1110002E03Rik, DS-1, ICT1, mitochondrial ribosomal protein L58, mL62 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human MRPL58 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- aminoacyl-tRNA hydrolase
- translation release factor activity, codon nonspecific
- enzyme
- translation release factor
- RF-1 domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- ribosome
- Plasma Membrane
- Mitochondria
- mitochondrial matrix
- mitochondrial inner membrane
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human MRPL58 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- rescue of stalled ribosome
- mitochondrial translational termination
- mitochondrial translation
Cellular Component
Where in the cell the gene product is active
- mitochondrial matrix
- mitochondrion
- mitochondrial large ribosomal subunit
- mitochondrial inner membrane
- plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- translation release factor activity, codon nonspecific
- aminoacyl-tRNA hydrolase activity