RPL10 Gene Summary [Human]

This gene encodes a ribosomal protein that is a component of the 60S ribosome subunit. The related protein in chicken can bind to c-Jun and can repress c-Jun-mediated transcriptional activation. Some studies have detected an association between variation in this gene and autism spectrum disorders, though others do not detect this relationship. There are multiple pseudogenes of this gene dispersed throughout the genome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]

Details

Type
Retained Intron
Official Symbol
RPL10
Official Name
ribosomal protein L10 [Source:HGNC Symbol;Acc:HGNC:10298]
Ensembl ID
ENSG00000147403
Bio databases IDs NCBI: 6134 Ensembl: ENSG00000147403
Aliases ribosomal protein L10
Synonyms AUTSX5, D0HXS648, DXHXS648, DXHXS648E, DXS648, DXS648E, JIF1, L10, MRXS35, NOV, QM, QM16, Ribosomal protein 10, ribosomal protein L10, Tumor suppressor QM, tumour suppressor QM, uL16
Species
Human, Homo sapiens
OrthologiesMouseRat

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human RPL10 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • structural constituent of ribosome
  • Ribosomal_L16_L10e
  • Ribosomal protein L16p/L10e
  • protein binding
  • zinc finger domain
  • translation regulator

Pathways

Biological processes and signaling networks where the RPL10 gene in human plays a role, providing insight into its function and relevance in health or disease.

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
  • T acute lymphoblastic leukemia
  • syndromic X-linked mental retardation type 35
  • COVID-19
  • syndromic X-linked mental retardation
  • susceptibility to X-linked autism type 5
  • oral squamous cell carcinoma
  • squamous cell cancer of the oral cavity
regulated by
regulates
  • TCF7L2
  • DNA promoter
  • DNA endogenous promoter
  • RNA polymerase II
  • YES1
  • LEF1
role in cell
  • apoptosis
  • proliferation
  • cell death
  • transactivation in
  • necroptosis
  • translation in

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Cytoplasm
  • pH resistant lipid raft fraction
  • cellular membrane
  • ribosome
  • Nucleus
  • Endoplasmic Reticulum
  • cytosol
  • synapse
  • smooth endoplasmatic reticulum

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the human RPL10 gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • negative regulation of transcription from RNA polymerase II promoter
  • regulation of translation
  • negative regulation of apoptotic process
  • cytoplasmic translation
  • ribosomal large subunit assembly
  • translation

Cellular Component

Where in the cell the gene product is active
  • nucleus
  • cytosolic ribosome
  • smooth endoplasmic reticulum
  • membrane
  • cytosol
  • endoplasmic reticulum
  • macromolecular complex
  • cytosolic large ribosomal subunit

Molecular Function

What the gene product does at the molecular level
  • translation regulator activity
  • protein binding
  • RNA binding
  • structural constituent of ribosome

Gene-Specific Assays for Results You Can Trust

Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.