RAB26 Gene Summary [Human]
Members of the RAB protein family, including RAB26, are important regulators of vesicular fusion and trafficking. The RAB family of small G proteins regulates intercellular vesicle trafficking, including exocytosis, endocytosis, and recycling (summary by Seki et al., 2000 [PubMed 11043516]).[supplied by OMIM, Nov 2010]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | RAB26 |
| Official Name | RAB26, member RAS oncogene family [Source:HGNC Symbol;Acc:HGNC:14259] |
| Ensembl ID | ENSG00000167964 |
| Bio databases IDs | |
| Aliases | RAB26, member RAS oncogene family |
| Synonyms | A830020M03RIK, RAB26, member RAS oncogene family, V46133 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human RAB26 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Small GTPase of the Ras superfamily (ill-defined subfamily)
- Ras family
- GTPase
- enzyme
- protein binding
- Ras subfamily of RAS small GTPases
- GTP binding
- GMP binding
- small GTP-binding protein domain
- Rab subfamily of small GTPases
- Ras of Complex, Roc, domain of DAPkinase
- Rho (Ras homology) subfamily of Ras-like small GTPases
- P-loop containing Nucleoside Triphosphate Hydrolases
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- intracellular nanovesicle
- synaptic vesicle membrane
- secretory granule membrane
- Golgi membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human RAB26 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- exocrine system development
- regulated secretory pathway
- Golgi to plasma membrane protein transport
- regulation of exocytosis
Cellular Component
Where in the cell the gene product is active
- secretory granule membrane
- endosome
- Golgi membrane
- Golgi apparatus
- synaptic vesicle membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- GTP binding
- protein binding
- GTPase activity
- GMP binding