ADRA2B Gene Summary [Human]
This intronless gene encodes a seven-pass transmembrane protein. This protein is a member of a subfamily of G protein-coupled receptors that regulate neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. [provided by RefSeq, Apr 2014]
Details
| Type | Protein Coding |
| Official Symbol | ADRA2B |
| Official Name | adrenoceptor alpha 2B [Source:HGNC Symbol;Acc:HGNC:282] |
| Ensembl ID | ENSG00000274286 |
| Bio databases IDs | |
| Aliases | adrenoceptor alpha 2B |
| Synonyms | [a]2B, a2b-AR, ADRA2L1, ADRA2RL1, ADRARL1, adrenergic receptor, alpha 2b, adrenergic receptor, α 2b, adrenoceptor alpha 2B, adrenoceptor α 2B, alpha2B, ALPHA2BAR, alpha2-C2, alpha2-C2-AR, FAME2, α 2b adrenergic receptor, α-2BAR |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ADRA2B often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- adrenoceptor
- hormone binding
- intracellular loop
- binding protein
- intracellular domain
- protein binding
- seven-transmembrane G protein-coupled receptor superfamily
- alpha2-adrenergic receptor
Pathways
Biological processes and signaling networks where the ADRA2B gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- nausea
- infection
- juvenile rheumatoid arthritis
- sepsis
- gastric cancer
- major depression
- schizophrenia
- Alzheimer disease
- mania
- psychological disorder
role in cell
- expression in
- binding in
- morphology
- differentiation
- proliferation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- membrane fraction
- intracellular membrane-bounded organelle
- cell surface
- cellular membrane
- cytosol
- basolateral cell surfaces
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ADRA2B gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- G-protein coupled receptor signaling pathway
- cell-cell signaling
- positive regulation of neuron differentiation
- female pregnancy
- positive regulation of MAPK cascade
- regulation of vascular smooth muscle contraction
- positive regulation of blood pressure
- MAPK cascade
- positive regulation of uterine smooth muscle contraction
- angiogenesis
- adenylate cyclase-activating adrenergic receptor signaling pathway
- receptor transactivation
- adrenergic receptor signaling pathway
- negative regulation of norepinephrine secretion
- platelet activation
- negative regulation of epinephrine secretion
- activation of protein kinase B activity
Cellular Component
Where in the cell the gene product is active
- intracellular membrane-bounded organelle
- cytosol
- plasma membrane
- cell surface
Molecular Function
What the gene product does at the molecular level
- epinephrine binding
- protein binding
- alpha2-adrenergic receptor activity