GLYCTK Gene Summary [Human]
This locus encodes a member of the glycerate kinase type-2 family. The encoded enzyme catalyzes the phosphorylation of (R)-glycerate and may be involved in serine degradation and fructose metabolism. Decreased activity of the encoded enzyme may be associated with the disease D-glyceric aciduria. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jan 2009]
Details
| Type | Protein Coding |
| Official Symbol | GLYCTK |
| Official Name | glycerate kinase [Source:HGNC Symbol;Acc:HGNC:24247] |
| Ensembl ID | ENSG00000168237 |
| Bio databases IDs | |
| Aliases | glycerate kinase |
| Synonyms | 6230410P16RIK, C430006L12, glycerate kinase, HBeAgBP4A, HBEBP2, HBEBP4 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human GLYCTK often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- MOFRL family
- glycerate kinase
- protein binding
- Domain of unknown function (DUF4147)
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Golgi Apparatus
- Mitochondria
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human GLYCTK gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein phosphorylation
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- mitochondrion
- cytosol
- Golgi apparatus
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein binding
- glycerate kinase activity