CALCOCO2 Gene Summary [Human]
This gene encodes a coiled-coil domain-containing protein. The encoded protein functions as a receptor for ubiquitin-coated bacteria and plays an important role in innate immunity by mediating macroautophagy. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, May 2012]
Details
| Type | Protein Coding |
| Official Symbol | CALCOCO2 |
| Official Name | calcium binding and coiled-coil domain 2 [Source:HGNC Symbol;Acc:HGNC:29912] |
| Ensembl ID | ENSG00000136436 |
| Bio databases IDs | |
| Aliases | calcium binding and coiled-coil domain 2 |
| Synonyms | 2410154J16Rik, calcium binding and coiled-coil domain 2, NDP52, NDP52L1, NUCLEAR domain 10 protein 52, RGD1559974 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CALCOCO2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- UBZ domain
- SKICH domain
- Modifier of rudimentary (Mod(r)) protein
- Tropomyosin like
- Zn-C2H2_CALCOCO1_TAX1BP1_like
- Growth-arrest specific micro-tubule binding
- protein homodimerization
- protein binding
- Autophagy receptor zinc finger-C2H2 domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- non-insulin-dependent diabetes mellitus
- mucoepidermoid carcinoma
- serous ovarian adenocarcinoma
- serous ovarian cancer
role in cell
- degradation in
- proliferation
- apoptosis
- maturation
- proliferation in
- autophagy
- autophagy by
- autophagy in
- degradation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- intracellular membrane-bounded organelle
- Cytoplasm
- perinuclear region
- cytosol
- autophagic vacuoles
- PML nuclear bodies
- cytoskeletal fraction
- cytoplasmic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human CALCOCO2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- response to interferon-gamma
- viral reproduction
Cellular Component
Where in the cell the gene product is active
- nucleus
- perinuclear region of cytoplasm
- cytoskeleton
- PML body
- cytoplasm
- intracellular membrane-bounded organelle
- membrane
- cytosol
- cytoplasmic vesicle
- autophagic vacuole
- autophagic vacuole membrane
Molecular Function
What the gene product does at the molecular level
- protein homodimerization activity
- protein binding
- metal ion binding