TMEM208 Gene Summary [Human]
This gene encodes a highly conserved protein which is localized in the endoplasmic reticulum (ER). The protein is linked to autophagy and ER stress. Knockdown of this gene increased autophagy and triggered ER stress. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]
Details
| Type | Retained Intron |
| Official Symbol | TMEM208 |
| Official Name | transmembrane protein 208 [Source:HGNC Symbol;Acc:HGNC:25015] |
| Ensembl ID | ENSG00000168701 |
| Bio databases IDs | |
| Aliases | transmembrane protein 208, SRP-independent targeting 2 homolog |
| Synonyms | 1700006C06Rik, 2610030K20Rik, hSND2, HSPC171, RGD1560953, SND2, transmembrane protein 208 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human TMEM208 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SRP-independent targeting protein 2/TMEM208
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- endoplasmic reticulum membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human TMEM208 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- vacuolar protein processing
- autophagy
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- vacuole
Molecular Function
What the gene product does at the molecular level
- protein binding