LCMT2 Gene Summary [Human]
The protein encoded by this intronless gene belongs to the highly variable methyltransferase superfamily. This gene is the inferred homolog of the Saccharomyces cerevisiae carboxymethyltransferase gene PPM2 that is essential for the synthesis of the hypermodified guanosine Wybutosine (yW). [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | LCMT2 |
| Official Name | leucine carboxyl methyltransferase 2 [Source:HGNC Symbol;Acc:HGNC:17558] |
| Ensembl ID | ENSG00000168806 |
| Bio databases IDs | |
| Aliases | leucine carboxyl methyltransferase 2, tRNA-yW synthesizing protein 4 |
| Synonyms | D330024M17, leucine carboxyl methyltransferase 2, PPM2, TYW4 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human LCMT2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- tRNA methyltransferase
- C-terminal protein carboxyl methyltransferase
- Sugar-binding cellulase-like
- enzyme
- protein binding
- AdoMet_MTases
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human LCMT2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- wybutosine biosynthetic process
- tRNA methylation
- tRNA modification
Cellular Component
Where in the cell the gene product is active
- cytoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- tRNA methyltransferase activity