FGL1 Gene Summary [Human]
Fibrinogen-like 1 is a member of the fibrinogen family. This protein is homologous to the carboxy terminus of the fibrinogen beta- and gamma- subunits which contains the four conserved cysteines of fibrinogens and fibrinogen related proteins. However, this protein lacks the platelet-binding site, cross-linking region and a thrombin-sensitive site which are necessary for fibrin clot formation. This protein may play a role in the development of hepatocellular carcinomas. Four alternatively spliced transcript variants encoding the same protein exist for this gene. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | FGL1 |
| Official Name | fibrinogen like 1 [Source:HGNC Symbol;Acc:HGNC:3695] |
| Ensembl ID | ENSG00000104760 |
| Bio databases IDs | |
| Aliases | fibrinogen like 1, hepassocin |
| Synonyms | fibrinogen-like 1, fibrinogen-like protein 1, Frep1, Hepassocin, HFREP1, HP-041, HPS, LFIRE-1, Mfire1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human FGL1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein binding
- identical protein binding
- FReD
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- hepatocellular carcinoma
- weight gain
- hyperglycemia
- epithelial cancer
- liver cancer
- bronchiolo-alveolar adenocarcinoma
- broncho-alveolar lung cancer
- fasting hyperglycemia
- preeclampsia
role in cell
- expression in
- growth
- apoptosis
- proliferation
- activation
- number
- size
- abnormal morphology
- colony formation by
- proliferation by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Cytoplasm
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human FGL1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell-matrix adhesion
- hepatocyte proliferation
- adaptive immune response
- negative regulation of T cell activation
- platelet aggregation
- regulation of immune response
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular region
- fibrinogen complex
Molecular Function
What the gene product does at the molecular level
- protein binding
- receptor binding