BAG5 Gene Summary [Human]
The protein encoded by this gene is a member of the BAG1-related protein family. BAG1 is an anti-apoptotic protein that functions through interactions with a variety of cell apoptosis and growth related proteins including BCL-2, Raf-protein kinase, steroid hormone receptors, growth factor receptors and members of the heat shock protein 70 kDa family. This protein contains a BAG domain near the C-terminus, which could bind and inhibit the chaperone activity of Hsc70/Hsp70. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | BAG5 |
| Official Name | BAG cochaperone 5 [Source:HGNC Symbol;Acc:HGNC:941] |
| Ensembl ID | ENSG00000166170 |
| Bio databases IDs | |
| Aliases | BAG cochaperone 5 |
| Synonyms | 1600025G07Rik, 4930405J06Rik, Bag5l1, BAG cochaperone 5, BCL2-associated athanogene 5, CMD2F |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human BAG5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ubiquitin protein ligase binding
- BAG domains, present in regulator of Hsp70 proteins
- protein kinase binding
- enzyme inhibitor activity
- BAG domain
- protein binding
- enzyme regulator activity
- chaperone binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- dilated cardiomyopathy type 2F
- peripheral arterial disease
- neurodegeneration
- cardiomyopathy
role in cell
- cell death
- apoptosis
- development
- assembly
- organization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- junctional membrane complex
- intracellular space
- perinuclear region
- Nucleus
- Mitochondria
- cytosol
- exosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human BAG5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of ubiquitin-protein ligase activity
- negative regulation of neuron projection development
- Golgi organization
- negative regulation of protein ubiquitination
- negative regulation of protein refolding
- protein stabilization
- regulation of inclusion body assembly
- protein folding
- regulation of ubiquitin-protein ligase activity
- negative regulation of proteasomal ubiquitin-dependent protein catabolic process
Cellular Component
Where in the cell the gene product is active
- nucleus
- perinuclear region of cytoplasm
- cytoplasm
- membrane
- mitochondrion
- cytosol
- inclusion body
- junctional membrane complex
Molecular Function
What the gene product does at the molecular level
- protein kinase binding
- protein binding
- ubiquitin protein ligase binding
- chaperone binding
- adenyl-nucleotide exchange factor activity