CDC5L Gene Summary [Human]
The protein encoded by this gene shares a significant similarity with Schizosaccharomyces pombe cdc5 gene product, which is a cell cycle regulator important for G2/M transition. This protein has been demonstrated to act as a positive regulator of cell cycle G2/M progression. It was also found to be an essential component of a non-snRNA spliceosome, which contains at least five additional protein factors and is required for the second catalytic step of pre-mRNA splicing. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | CDC5L |
| Official Name | cell division cycle 5 like [Source:HGNC Symbol;Acc:HGNC:1743] |
| Ensembl ID | ENSG00000096401 |
| Bio databases IDs | |
| Aliases | cell division cycle 5 like |
| Synonyms | 1200002I02Rik, CDC5, CDC5-LIKE, CEF1, cell division cycle 5-like, dJ319D22.1, PCDC5RP |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CDC5L often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- SANT
- transcription regulator
- SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
- protein kinase binding
- nucleic acid binding
- LRR-domain binding
- pre-mRNA splicing factor component
- transcription factor binding
- protein domain specific binding
- protein binding
- sequence-specific DNA binding
- identical protein binding
- protein phosphatase 1 binding
- double-stranded DNA binding
- Myb-like DNA-binding domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- ischemic stroke
- diabetic nephropathy
role in cell
- morphology
- response by
- Clathrin mediated endocytosis by
- splicing by
- replication in
- JQ1 resistance
- alternative splicing in
- G2/M phase transition
- processing in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- catalytic step 2 spliceosome
- Cytoplasm
- perinuclear region
- spliceosomes
- nucleoplasm
- interchromatin granule clusters
- nuclear speckles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human CDC5L gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- DNA repair
- DNA damage checkpoint
- positive regulation of transcription from RNA polymerase II promoter
- regulation of transcription from RNA polymerase II promoter
- nuclear mRNA splicing, via spliceosome
Cellular Component
Where in the cell the gene product is active
- nucleus
- catalytic step 2 spliceosome
- cytoplasm
- nuclear speck
- membrane
- U2-type catalytic step 2 spliceosome
- spliceosomal complex
- DNA replication factor A complex
- Prp19 complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding
- identical protein binding
- RNA binding
- protein binding
- RNA polymerase II regulatory region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
- WD40-repeat domain binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity