SPRY3 Gene Summary [Human]
Involved in negative regulation of MAPK cascade. Predicted to be located in membrane. Predicted to be active in cytosol. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Processed Transcript |
| Official Symbol | SPRY3 |
| Official Name | sprouty RTK signaling antagonist 3 [Source:HGNC Symbol;Acc:HGNC:11271] |
| Ensembl ID | ENSG00000168939 |
| Bio databases IDs | |
| Aliases | sprouty RTK signaling antagonist 3, antagonist of FGF signaling |
| Synonyms | Gm1409, Gm391, RGD1562172, sprouty3, sprouty RTK signaling antagonist 3, SPRY3X |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human SPRY3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein binding
- zDHHC ankyrin repeat binding domain
- Sprouty protein (Spry)
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- membrane ruffles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human SPRY3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of fibroblast growth factor receptor signaling pathway
- negative regulation of MAP kinase activity
- negative regulation of Ras protein signal transduction
- negative regulation of MAPK cascade
- negative regulation of ERK1 and ERK2 cascade
- nervous system development
- organ development
Cellular Component
Where in the cell the gene product is active
- membrane
- cytosol
Molecular Function
What the gene product does at the molecular level
- protein binding