BEX2 Gene Summary [Human]
This gene belongs to the brain expressed X-linked gene family. The encoded protein interacts with the transcription factor LIM domain only 2 in a DNA-binding complex that recognizes the E-box element and promotes transcription. This gene has been found to be a tumor suppressor that is silenced in human glioma. In breast cancer cells, this gene product modulates apoptosis in response to estrogen and tamoxifen, and enhances the anti-proliferative effect of tamoxifen. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2009]
Details
| Type | Protein Coding |
| Official Symbol | BEX2 |
| Official Name | brain expressed X-linked 2 [Source:HGNC Symbol;Acc:HGNC:30933] |
| Ensembl ID | ENSG00000133134 |
| Bio databases IDs | |
| Aliases | brain expressed X-linked 2 |
| Synonyms | BEX1, Bex4, brain expressed X-linked 1, brain expressed X-linked 2, DJ79P11.1, Rex3 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human BEX2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Brain expressed X-linked like family
- transcription factor binding
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cancer
- neoplasia
- organismal death
- breast carcinoma
- lung adenocarcinoma
- lung adenocarcinoma formation
- tuberous sclerosis complex
role in cell
- cell death
- proliferation
- apoptosis
- survival
- production in
- binding in
- quantity
- ferroptosis
- differentiation
- cell cycle progression
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- Cytoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human BEX2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- signal transduction
- apoptotic process
- regulation of apoptotic process
- negative regulation of protein ubiquitination
- regulation of cell cycle
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- metal ion binding
- receptor binding