APLF Gene Summary [Human]
Enables DNA-(apurinic or apyrimidinic site) endonuclease activity; nuclease activity; and nucleotide binding activity. Involved in double-strand break repair via nonhomologous end joining and single strand break repair. Acts upstream of or within positive regulation of DNA ligation. Located in nucleoplasm. Is active in site of double-strand break. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | APLF |
| Official Name | aprataxin and PNKP like factor [Source:HGNC Symbol;Acc:HGNC:28724] |
| Ensembl ID | ENSG00000169621 |
| Bio databases IDs | |
| Aliases | aprataxin and PNKP like factor, XRCC1-interacting protein 1, zinc finger, CX5CX6HX5H motif containing 1 |
| Synonyms | 2010301N04Rik, APFL, aprataxin and PNKP like factor, C2orf13, PALF, RGD1565557, Xip1, ZCCHH1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human APLF often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- histone binding
- 3'-5' exonuclease
- nucleotide binding
- DNA-(apurinic or apyrimidinic site) lyase
- Ku binding domain
- enzyme
- protein binding
- acidic domain
- forkhead associated (FHA) domain superfamily
- endonuclease
- binding protein
- PBZ domain
- FHA domain
- zinc finger domain
- MID domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- acute myeloid leukemia
- tinnitus
role in cell
- survival
- double-stranded DNA break repair
- double-stranded DNA break repair in
- retention in
- non-homologous end joining in
- DNA damage response
- ligation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human APLF gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- single strand break repair
- regulation of epithelial to mesenchymal transition
- DNA repair
- protein localization to chromatin
- regulation of isotype switching
- double-strand break repair via nonhomologous end joining
- protein folding
- response to DNA damage stimulus
- embryo implantation
- double-strand break repair
- positive regulation of DNA ligation
Cellular Component
Where in the cell the gene product is active
- nucleus
- site of double-strand break
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- poly-ADP-D-ribose binding
- nucleotide binding
- 3'-5' exonuclease activity
- protein binding
- protein binding involved in protein folding
- histone binding
- metal ion binding
- DNA-(apurinic or apyrimidinic site) lyase activity
- endodeoxyribonuclease activity