SUPT16H Gene Summary [Human]
Transcription of protein-coding genes can be reconstituted on naked DNA with only the general transcription factors and RNA polymerase II. However, this minimal system cannot transcribe DNA packaged into chromatin, indicating that accessory factors may facilitate access to DNA. One such factor, FACT (facilitates chromatin transcription), interacts specifically with histones H2A/H2B to effect nucleosome disassembly and transcription elongation. FACT is composed of an 80 kDa subunit and a 140 kDa subunit; this gene encodes the 140 kDa subunit. [provided by RefSeq, Feb 2009]
Details
| Type | Protein Coding |
| Official Symbol | SUPT16H |
| Official Name | SPT16 homolog, facilitates chromatin remodeling subunit [Source:HGNC Symbol;Acc:HGNC:11465] |
| Ensembl ID | ENSG00000092201 |
| Bio databases IDs | |
| Aliases | SPT16 homolog, facilitates chromatin remodeling subunit, facilitates chromatin remodeling 140 kDa subunit |
| Synonyms | CDC68, Fact140, FACTP140, FLJ10857, LOC100505120, NEDDFAC, SPT16, SPT16/CDC68, SPT16, facilitates chromatin remodeling subunit, SPT16 homolog, facilitates chromatin remodeling subunit, Supt16 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human SUPT16H often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- FACT complex subunit (SPT16/CDC68)
- Metallopeptidase family M24
- transcription regulator
- FACT complex subunit SPT16 N-terminal lobe domain
- protein binding
- APP_MetAP
- Histone chaperone Rttp106-like
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neurodevelopmental disorder with dysmorphic facies and thin corpus callosum
- Hutchinson-Gilford progeria syndrome
- pleural mesothelioma
- mesothelioma formation
role in cell
- expression in
- survival
- cell death
- transcription in
- elongation in
- binding in
- disassembly
- reactivation in
- deposition in
- opening in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- nucleoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human SUPT16H gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- DNA repair
- DNA replication
- transcription from RNA polymerase II promoter
- nucleosome disassembly
- nucleosome assembly
- positive regulation of transcription elongation, DNA-dependent
- transcription elongation from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- FACT complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- RNA binding
- protein binding
- nucleosome binding