Aplf Gene Summary [Mouse]
Predicted to enable several functions, including ADP-D-ribose modification-dependent protein binding activity; nuclease activity; and poly-ADP-D-ribose binding activity. Involved in embryo implantation and regulation of epithelial to mesenchymal transition. Acts upstream of or within double-strand break repair and regulation of isotype switching. Is active in cytosol and nucleus. Is expressed in allantois; blastocyst; and early embryo. Orthologous to human APLF (aprataxin and PNKP like factor). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Aplf |
| Official Name | aprataxin and PNKP like factor [Source:MGI Symbol;Acc:MGI:1919353] |
| Ensembl ID | ENSMUSG00000030051 |
| Bio databases IDs | |
| Aliases | aprataxin and PNKP like factor |
| Synonyms | 2010301N04Rik, APFL, aprataxin and PNKP like factor, C2orf13, PALF, RGD1565557, Xip1, ZCCHH1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Aplf often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- histone binding
- 3'-5' exonuclease
- nucleotide binding
- DNA-(apurinic or apyrimidinic site) lyase
- Ku binding domain
- enzyme
- protein binding
- acidic domain
- forkhead associated (FHA) domain superfamily
- endonuclease
- binding protein
- PBZ domain
- FHA domain
- zinc finger domain
- MID domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- acute myeloid leukemia
- tinnitus
role in cell
- survival
- double-stranded DNA break repair
- double-stranded DNA break repair in
- retention in
- non-homologous end joining in
- DNA damage response
- ligation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Aplf gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- single strand break repair
- regulation of epithelial to mesenchymal transition
- DNA repair
- protein localization to chromatin
- regulation of isotype switching
- double-strand break repair via nonhomologous end joining
- protein folding
- response to DNA damage stimulus
- embryo implantation
- double-strand break repair
- positive regulation of DNA ligation
Cellular Component
Where in the cell the gene product is active
- nucleus
- site of double-strand break
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- poly-ADP-D-ribose binding
- nucleotide binding
- 3'-5' exonuclease activity
- protein binding
- protein binding involved in protein folding
- histone binding
- metal ion binding
- DNA-(apurinic or apyrimidinic site) lyase activity
- endodeoxyribonuclease activity