DRD5 Gene Summary [Human]
This gene encodes the D5 subtype of the dopamine receptor. The D5 subtype is a G-protein coupled receptor which stimulates adenylyl cyclase. This receptor is expressed in neurons in the limbic regions of the brain. It has a 10-fold higher affinity for dopamine than the D1 subtype. Pseudogenes related to this gene reside on chromosomes 1 and 2. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | DRD5 |
| Official Name | dopamine receptor D5 [Source:HGNC Symbol;Acc:HGNC:3026] |
| Ensembl ID | ENSG00000169676 |
| Bio databases IDs | |
| Aliases | dopamine receptor D5 |
| Synonyms | D1B, D5R, DBDR, DOPAMINE D5 receptor, dopamine receptor D5, DRD1B, DRD1L2, Gpcr1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human DRD5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- Cholecystokinin A receptor, N-terminal
- binding protein
- cytoplasmic domain
- dopamine receptor
- extracellular loop
- 7 transmembrane receptor (rhodopsin family)
- tail domain
- protein binding
- dopamine D1 receptor-like receptor
- seven-transmembrane G protein-coupled receptor superfamily
Pathways
Biological processes and signaling networks where the DRD5 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- infection
- plasma cell myeloma
- septic shock
- acute renal failure
- diabetes mellitus
- severe sepsis
- nausea
- vomiting
- hypertension
- Alzheimer disease
role in cell
- production in
- proliferation
- activation in
- expression in
- migration
- activation
- binding in
- synthesis in
- homeostasis in
- signaling in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- membrane fraction
- glutaminergic synapse
- non-motile cilium
- Cytoplasm
- cilia
- cell surface
- cellular membrane
- synaptic membrane
- dendritic spines
- membrane rafts
- brush border
- perikaryon
- axons
- dendrites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human DRD5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- adenylate cyclase-activating dopamine receptor signaling pathway
- regulation of female receptivity
- dopamine receptor signaling pathway
- positive regulation of adenylate cyclase activity
- associative learning
- regulation of systemic arterial blood pressure by vasopressin
- wound healing
- synaptic transmission, dopaminergic
- sensitization
- cellular response to catecholamine stimulus
- long term synaptic depression
- transmission of nerve impulse
- activation of adenylate cyclase activity
- response to cocaine
- negative regulation of blood pressure
- synaptic transmission
- positive regulation of MAPK cascade
- adenylate cyclase-activating G-protein coupled receptor signaling pathway
- phospholipase C-activating dopamine receptor signaling pathway
- cellular calcium ion homeostasis
- norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure
- reactive oxygen species metabolic process
- response to amphetamine
- adenylate cyclase-activating adrenergic receptor signaling pathway
- negative regulation of NAD(P)H oxidase activity
Cellular Component
Where in the cell the gene product is active
- brush border membrane
- cilium
- cilium membrane
- synapse
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- G-protein coupled receptor activity
- dopamine receptor activity
- dopamine receptor activity, coupled via Gs
- protein binding
- dopamine binding