TM4SF4 Gene Summary [Human]
The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that can regulate cell proliferation.[provided by RefSeq, Mar 2011]
Details
| Type | Protein Coding |
| Official Symbol | TM4SF4 |
| Official Name | transmembrane 4 L six family member 4 [Source:HGNC Symbol;Acc:HGNC:11856] |
| Ensembl ID | ENSG00000169903 |
| Bio databases IDs | |
| Aliases | transmembrane 4 L six family member 4 |
| Synonyms | ILTMP, LOC108350014, Lrtm4, transmembrane 4 L six family member 4, transmembrane 4 superfamily member 4 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human TM4SF4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- L6 membrane protein
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- cholecystitis
- colon cancer
- cholelithiasis
- single major depressive episode
- major depression
- coronary artery disease
- gout
- gallstone
- gallbladder polyp
regulates
- actin
role in cell
- proliferation
- migration
- colony formation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human TM4SF4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- tissue regeneration
Cellular Component
Where in the cell the gene product is active
- membrane
Molecular Function
What the gene product does at the molecular level
- protein binding