KCNK5 Gene Summary [Human]
This gene encodes one of the members of the superfamily of potassium channel proteins containing two pore-forming P domains. The message for this gene is mainly expressed in the cortical distal tubules and collecting ducts of the kidney. The protein is highly sensitive to external pH and this, in combination with its expression pattern, suggests it may play an important role in renal potassium transport. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | KCNK5 |
| Official Name | potassium two pore domain channel subfamily K member 5 [Source:HGNC Symbol;Acc:HGNC:6280] |
| Ensembl ID | ENSG00000164626 |
| Bio databases IDs | |
| Aliases | potassium two pore domain channel subfamily K member 5, TWIK-related acid-sensitive K+ 2 |
| Synonyms | FLJ11035, K2p5.1, KCNK5b, LOC364241, potassium channel, subfamily K, member 5, potassium two pore domain channel subfamily K member 5, TASK-2 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human KCNK5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- potassium channel
- outward rectifier potassium channel
- voltage-gated potassium channel
- protein binding
- ion channel
- protein heterodimerization
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- open-angle glaucoma
- albuminuria
- migraines
- coronary artery disease
- hyperventilation
- vascular dementia
- respiratory depression
- kidney stones
- hypertension
- pancreatic carcinoma
regulates
- Na+
- bicarbonate
- water
- K+
role in cell
- adhesion
- proliferation
- dipeptide repeat protein sensitivity
- function
- glycolysis in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell periphery
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human KCNK5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- potassium ion transport
- potassium ion transmembrane transport
- regulation of resting membrane potential
- stabilization of membrane potential
Cellular Component
Where in the cell the gene product is active
- ion channel complex
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- outward rectifier potassium channel activity
- potassium channel activity
- potassium ion leak channel activity