KRT74 Gene Summary [Human]

Keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into epithelial keratins and hair keratins. This protein belongs to a family of keratins that are specifically expressed in the inner root sheath of hair follicles.[provided by RefSeq, Jun 2009]

Details

Type
Protein Coding
Official Symbol
KRT74
Official Name
keratin 74 [Source:HGNC Symbol;Acc:HGNC:28929]
Ensembl ID
ENSG00000170484
Bio databases IDs NCBI: 121391 Ensembl: ENSG00000170484
Aliases keratin 74
Synonyms ADWH, CYTOKERATIN 5C, ECTD7, HTSS2, HYPT3, K6IRS4, keratin 74, KRT5C, KRT6IRS4
Species
Human, Homo sapiens

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human KRT74 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • intermediate filament binding
  • protein binding
  • Intermediate filament protein
  • Keratin type II head

Pathways

Biological processes and signaling networks where the KRT74 gene in human plays a role, providing insight into its function and relevance in health or disease.

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
  • autosomal dominant woolly hair
  • androgenic alopecia
  • hypotrichosis type 3
  • hair/nail type ectodermal dysplasia type 7
  • hair/nail type ectodermal dysplasia type 4
  • venous thromboembolism
role in cell
  • organization

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Cytoplasm
  • cytosol

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the human KRT74 gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • intermediate filament cytoskeleton organization
  • keratinization
  • intermediate filament organization

Cellular Component

Where in the cell the gene product is active
  • extracellular vesicular exosome
  • keratin filament
  • cytoplasm
  • cytosol

Molecular Function

What the gene product does at the molecular level
  • structural constituent of epidermis
  • protein binding

Gene-Specific Assays for Results You Can Trust

Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.