KRT36 Gene Summary [Human]
The protein encoded by this gene is a member of the keratin gene family. This type I hair keratin is an acidic protein which heterodimerizes with type II keratins to form hair and nails. The type I hair keratins are clustered in a region of chromosome 17q12-q21 and have the same direction of transcription. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | KRT36 |
| Official Name | keratin 36 [Source:HGNC Symbol;Acc:HGNC:6454] |
| Ensembl ID | ENSG00000126337 |
| Bio databases IDs | |
| Aliases | keratin 36 |
| Synonyms | HA6, hHa6, HRa-1, K36, Ka31, keratin 36, Keratin complex 1, acidic, gene 5, Krt1-22, Krt1-5, KRTHA6, MHRa-1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human KRT36 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- structural constituent of epidermis
- protein binding
- Intermediate filament protein
- Spc7 kinetochore protein
Pathways
Biological processes and signaling networks where the KRT36 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- intermediate filament cytoskeleton
- cytosol
- keratin intermediate filaments
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human KRT36 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- epithelial cell differentiation
- regulation of keratinocyte differentiation
- intermediate filament organization
Cellular Component
Where in the cell the gene product is active
- keratin filament
- extracellular vesicular exosome
- intermediate filament cytoskeleton
- cytosol
Molecular Function
What the gene product does at the molecular level
- structural constituent of epidermis