TRIAP1 Gene Summary [Human]
Enables p53 binding activity. Contributes to phosphatidic acid transfer activity. Involved in several processes, including DNA damage response, signal transduction by p53 class mediator; negative regulation of apoptotic process; and positive regulation of phospholipid transport. Located in mitochondrial intermembrane space and nucleoplasm. Part of protein-containing complex. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | TRIAP1 |
| Official Name | TP53 regulated inhibitor of apoptosis 1 [Source:HGNC Symbol;Acc:HGNC:26937] |
| Ensembl ID | ENSG00000170855 |
| Bio databases IDs | |
| Aliases | TP53 regulated inhibitor of apoptosis 1, p53-inducible cell-survival factor, mitochondrial distribution and morphology 35 homolog (S. cerevisiae) |
| Synonyms | 1810015M01Rik, HSPC132, LOC687835, MDM35, NEWGENE 1586233, P53CSV, TP53 regulated inhibitor of apoptosis 1, WF-1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human TRIAP1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- lipid transporter
- phospholipid transporter
- Uncharacterized protein family (UPF0203)
- p53 binding
- protein binding
- transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- colon cancer
regulates
- DNA promoter
- DNA endogenous promoter
- phosphatidylserine
- RNA polymerase II
- phospholipid
- PGAM5
role in cell
- apoptosis
- molecular cleavage in
- josamycin sensitivity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- perinuclear region
- Mitochondria
- mitochondrial intermembrane space
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human TRIAP1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of phospholipid transport
- negative regulation of release of cytochrome c from mitochondria
- positive regulation of transcription from RNA polymerase II promoter
- DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
- regulation of membrane lipid distribution
- phospholipid translocation
- negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
- negative regulation of apoptotic process
- apoptotic process
- DNA damage response, signal transduction by p53 class mediator
- cellular response to UV
- phospholipid transport
Cellular Component
Where in the cell the gene product is active
- nucleus
- mitochondrial intermembrane space
- mitochondrion
- macromolecular complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- p53 binding
- protein binding