PGAM5 Gene Summary [Human]
Enables GTPase activator activity and protein serine/threonine phosphatase activity. Involved in necroptotic process. Located in mitochondrion. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | PGAM5 |
| Official Name | PGAM family member 5, mitochondrial serine/threonine protein phosphatase [Source:HGNC Symbol;Acc:HGNC:28763] |
| Ensembl ID | ENSG00000247077 |
| Bio databases IDs | |
| Aliases | PGAM family member 5, mitochondrial serine/threonine protein phosphatase |
| Synonyms | 2610528A17Rik, BXLBV68, MGC5352, PGAM family member 5, mitochondrial serine/threonine protein phosphatase, phosphoglycerate mutase family member 5, RGD1312028 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PGAM5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- binding protein
- Histidine phosphatase superfamily (branch 1)
- protein serine/threonine phosphatase
- protein phosphatase
- Phosphoglycerate mutase family
- phosphatase
- GTPase activator
- enzyme
- protein binding
- Histidine phosphatase domain
- ESGE motif
Pathways
Biological processes and signaling networks where the PGAM5 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- chronic lymphocytic leukemia
role in cell
- expression in
- growth
- phosphorylation in
- production in
- cell death
- formation
- formation in
- degeneration
- cellular infiltration by
- serine phosphorylation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria
- mitochondrial membrane
- mitochondrial nucleoids
- mitochondrial outer membrane
- mitochondrial inner membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PGAM5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- peptidyl-threonine dephosphorylation
- necroptosis
- positive regulation of mitochondrial fission
- macroautophagy
Cellular Component
Where in the cell the gene product is active
- mitochondrion
- mitochondrial outer membrane
- mitochondrial inner membrane
Molecular Function
What the gene product does at the molecular level
- protein serine/threonine phosphatase activity
- protein binding
- GTPase activator activity
- phosphatase activity
- myosin phosphatase activity