IMMP1L Gene Summary [Human]
The mitochondrial inner membrane peptidase (IMP) complex generates mature, active proteins in the mitochondrial intermembrane space by proteolytically removing the mitochondrial targeting presequence of nuclear-encoded proteins. IMP1 and IMP2 (IMMP2L; MIM 605977) are the catalytic subunits of the IMP complex (Burri et al., 2005 [PubMed 15814844]).[supplied by OMIM, Sep 2008]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | IMMP1L |
| Official Name | inner mitochondrial membrane peptidase subunit 1 [Source:HGNC Symbol;Acc:HGNC:26317] |
| Ensembl ID | ENSG00000148950 |
| Bio databases IDs | |
| Aliases | inner mitochondrial membrane peptidase subunit 1 |
| Synonyms | 1500034J20Rik, 2610528O17Rik, IMMP1, IMP1, IMP1 inner mitochondrial membrane peptidase-like (S. cerevisiae), IMP1-LIKE, inner mitochondrial membrane peptidase subunit 1, LOC687395 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human IMMP1L often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- signal peptidase I, bacterial type
- nickel-type superoxide dismutase maturation protease
- Signal peptidase, peptidase S26
- Peptidase_S24_S26
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human IMMP1L gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein processing involved in protein targeting to mitochondrion
- signal peptide processing
Cellular Component
Where in the cell the gene product is active
- mitochondrion
- mitochondrial inner membrane peptidase complex
- mitochondrial inner membrane
Molecular Function
What the gene product does at the molecular level
- serine-type endopeptidase activity