NMUR1 Gene Summary [Human]
Enables neuromedin U binding activity and neuromedin U receptor activity. Involved in several processes, including activation of phospholipase C activity; chloride transport; and second-messenger-mediated signaling. Is integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | NMUR1 |
| Official Name | neuromedin U receptor 1 [Source:HGNC Symbol;Acc:HGNC:4518] |
| Ensembl ID | ENSG00000171596 |
| Bio databases IDs | |
| Aliases | neuromedin U receptor 1 |
| Synonyms | (FM-3), FM-3, GPC-R, GPR66, neuromedin U receptor 1, NMU1, NMU1R, NmU-R |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human NMUR1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- neuromedin U receptor
- neuropeptide receptor
- 7 transmembrane receptor (rhodopsin family)
- neuromedin U binding
- seven-transmembrane G protein-coupled receptor superfamily
Pathways
Biological processes and signaling networks where the NMUR1 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- androgenic alopecia
role in cell
- growth
- formation
- cisplatin sensitivity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- membrane fraction
- cilia
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human NMUR1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of calcium-mediated signaling
- neuropeptide signaling pathway
- G-protein coupled receptor signaling pathway
- smooth muscle contraction
- phospholipase C-activating G-protein coupled receptor signaling pathway
- calcium-mediated signaling
- chloride transport
Cellular Component
Where in the cell the gene product is active
- membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- G-protein coupled receptor activity
- neuromedin U binding
- neuropeptide receptor activity
- neuromedin U receptor activity