IL25 Gene Summary [Human]
The protein encoded by this gene is a cytokine that shares sequence similarity with interleukin 17. This cytokine can induce NF-kappaB activation, and stimulate the production of interleukin 8. Both this cytokine and interleukin 17B are ligands for the cytokine receptor IL17BR. Studies of a similar gene in mice suggest that this cytokine may be a pro-inflammatory cytokine favoring the Th2-type immune response. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010]
Details
| Type | Protein Coding |
| Official Symbol | IL25 |
| Official Name | interleukin 25 [Source:HGNC Symbol;Acc:HGNC:13765] |
| Ensembl ID | ENSG00000166090 |
| Bio databases IDs | |
| Aliases | interleukin 25 |
| Synonyms | IL-17e, interleukin 25, RGD1561632 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human IL25 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- interleukin-17E receptor binding
- Interleukin-17
- cytokine
Pathways
Biological processes and signaling networks where the IL25 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- atopic dermatitis
- multiple sclerosis
- airway hyperresponsiveness
- experimental autoimmune encephalomyelitis
- hepatic steatosis
- Crohn disease
- colitis
- eosinophilia
- hyperplasia
- eosinophilic airway inflammation
role in cell
- expression in
- phosphorylation in
- production in
- activation in
- differentiation
- activation
- proliferation
- quantity
- number
- cellular infiltration by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Nucleus
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human IL25 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- inflammatory response to antigenic stimulus
- signal transduction
- eosinophil differentiation
- response to fungus
- positive regulation of transcription from RNA polymerase II promoter
- response to nematode
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular region
Molecular Function
What the gene product does at the molecular level
- interleukin-17E receptor binding
- cytokine activity