IL33 Gene Summary [Human]
The protein encoded by this gene is a cytokine that binds to the IL1RL1/ST2 receptor. The encoded protein is involved in the maturation of Th2 cells and the activation of mast cells, basophils, eosinophils and natural killer cells. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2015]
Details
| Type | Protein Coding |
| Official Symbol | IL33 |
| Official Name | interleukin 33 [Source:HGNC Symbol;Acc:HGNC:16028] |
| Ensembl ID | ENSG00000137033 |
| Bio databases IDs | |
| Aliases | interleukin 33, DVS27-related protein, nuclear factor for high endothelial venules, interleukin-1 family, member 11 |
| Synonyms | 9230117N10Rik, C9orf26, DVS27, IL1F11, interleukin 33, NFEHEV, NF-HEV, RGD1311155 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human IL33 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- hematopoietin/interferon-class (D200-domain) cytokine receptor ligand
- Interleukin 33
- IL-1-like domain
- chromatin binding domain
- homeolike domain
- protein binding
- cytokine
- beta-trefoil domain found in the interleukin-1 (IL-1) family of cytokines
Pathways
Biological processes and signaling networks where the IL33 gene in human plays a role, providing insight into its function and relevance in health or disease.
- Acute Phase Response Signaling
- Airway Inflammation in Asthma
- Airway Pathology in Chronic Obstructive Pulmonary Disease
- Atherosclerosis Signaling
- Cholecystokinin/Gastrin-mediated Signaling
- Communication between Innate and Adaptive Immune Cells
- Dendritic Cell Maturation
- FXR/RXR Activation
- Graft-versus-Host Disease Signaling
- Hepatic Cholestasis
- IL-10 Signaling
- IL-6 Signaling
- LPS/IL-1 Mediated Inhibition of RXR Function
- LXR/RXR Activation
- NF-κB Signaling
- p38 MAPK Signaling
- PPAR Signaling
- Role of Hypercytokinemia/hyperchemokinemia in the Pathogenesis of Influenza
- Role of Pattern Recognition Receptors in Recognition of Bacteria and Viruses
- Th1 and Th2 Activation Pathway
- Th2 Pathway
- Toll-like Receptor Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cancer
- neoplasia
- bleeding
- insulin resistance
- ovarian cancer
- hypothermia
- asthma
- systemic lupus erythematosus
- lupus nephritis
- epithelial cancer
role in cell
- activation in
- expression in
- proliferation
- quantity
- growth
- cellular infiltration by
- apoptosis
- activity
- production in
- accumulation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- heterochromatin
- intracellular membrane-bounded organelle
- Cytoplasm
- cell surface
- perinuclear region
- Nucleus
- cytosol
- nucleoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human IL33 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of cellular defense response
- microglial cell activation involved in immune response
- extrinsic apoptotic signaling pathway
- positive regulation of MHC class I biosynthetic process
- positive regulation of transcription from RNA polymerase II promoter
- positive regulation of MHC class II biosynthetic process
- positive regulation of oligodendrocyte differentiation
- negative regulation of transcription from RNA polymerase II promoter
- positive regulation of type 2 immune response
- positive regulation of macrophage activation
- negative regulation of immunoglobulin production
- positive regulation of immunoglobulin production
- defense response to virus
- positive regulation of tumor necrosis factor production
- negative regulation of interferon-gamma production
- positive regulation of chemokine production
- macrophage differentiation
- positive regulation of inflammatory response
- negative regulation of leukocyte migration
- type 2 immune response
- cellular response to mechanical stimulus
- positive regulation of interleukin-13 production
- positive regulation of nitric-oxide synthase biosynthetic process
- positive regulation of gene expression
- protein import into nucleus
- negative regulation of T-helper 1 type immune response
- gene expression
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process
- positive regulation of interleukin-6 production
- positive regulation of cytokine production
- positive regulation of interleukin-4 production
- positive regulation of interleukin-5 production
Cellular Component
Where in the cell the gene product is active
- nucleus
- extracellular space
- cytoplasm
- intracellular membrane-bounded organelle
- transport vesicle
- chromosome
- extracellular region
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- cytokine activity
- interleukin-33 receptor binding